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550 5.7.750: Blocked from sending from unregistered domains (Microsoft 365)

Your Microsoft 365 organization sent a lot of mail from domains that aren't added and verified in the tenant, so Microsoft blocked it.

By David Ray · Updated October 17, 2026 · How we research

Blocked The address is probably fine. The problem is how the mail was sent.

What the bounce message looks like

The wording changes from one provider to another. These are typical examples:

550 5.7.750 Service unavailable. Client blocked from sending from unregistered domains.

Common causes

How to fix it if you sent the email

If you manage the receiving or sending mail system

Free tool: paste the full bounce into the bounce message decoder to get a plain-English reading of every code in it.

Questions people ask

What does 550 5.7.750 mean?
Your Microsoft 365 organization sent a lot of mail from domains that aren't added and verified in the tenant, so Microsoft blocked it.
Is 550 5.7.750 a hard or soft bounce?
Blocked. The address is probably fine. The problem is how the mail was sent.
Should I remove the address after a 5.7.750 bounce?
No. Fix how the mail is sent; the address itself is probably fine.