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550 5.4.1: Recipient address rejected: access denied

Microsoft 365 refused the address. Usually the mailbox doesn't exist in that organization, and the organization has set Microsoft to reject unknown addresses.

By David Ray · Updated October 17, 2026 · How we research

Hard bounce The address is bad. Don't keep sending to it.

What the bounce message looks like

The wording changes from one provider to another. These are typical examples:

550 5.4.1 Recipient address rejected: Access denied. AS(201806281) (Microsoft 365)

Common causes

How to fix it if you sent the email

If you manage the receiving or sending mail system

Free tool: paste the full bounce into the bounce message decoder to get a plain-English reading of every code in it.

Questions people ask

What does 550 5.4.1 mean?
Microsoft 365 refused the address. Usually the mailbox doesn't exist in that organization, and the organization has set Microsoft to reject unknown addresses.
Is 550 5.4.1 a hard or soft bounce?
Hard bounce. The address is bad. Don't keep sending to it.
Should I remove the address after a 5.4.1 bounce?
Yes. Remove it from your list, or confirm a new address with the person first.